Cell details

multipolar Lugaro cell, nomenclature (acronym): Geurts et al. (G)

Related concepts
Cell type (class)Nomenclature (Acronym) DefinitionRelation of multipolar Lugaro cell
AnnotationReference Collator
globular cellLaine and Axelrad (LA)

These cells are found scattered in the different folia of the vermis, thus appearing to be distributed throughout the cerebellar cortex....The soma nearly always (14/15) lies in the upper third of the granular layer (Figs. 1, 2 and 4) or inside the PC layer. In all globular cells the soma has a multipolar morphology, with radiating dendrites, a pattern highly reminiscent of that of Golgi cells. The pericaryon is more or less rounded, most often globular, and has a mean great axis of 14.5 micrometers and a mean somatic area of 129 micrometers2 . Nevertheless, some somata are more or less triangular or polyedric. The outstanding majority of our neurons (12/15) have no more than three to four dendritic trunks (see Table 1) and, frequently, the neurites draw a cross-like figure: three thick dendrites extend at right angles from the three cardinal points of the soma, whilst the axon emerges at the fourth (Figs. 1, 2 and 4). ...The axon usually originates with a rather thick initial segment, directly from the pericaryon (13/15) or from a proximal dendrite. The axonal stem can either directly ascend into the molecular layer where it ramifies (Figs. 1, 4), or it may first engage in a descending course (Fig. 2), giving off several thick collaterals which, after making a hairpin turn, re-ascend towards the molecular layer in which they branch. Before reaching the molecular layer, these collaterals usually give off short beaded fibers ending inside the granular layer (Figs. 1, 2)....The axonal arborization in the molecular layer is quite intricate with rather profuse ramified branches. These fibers have a more or less homogeneous diameter, in the order of 1 micrometer, and exhibit numerous beaded swellings. They are mainly distributed in the inferior two thirds of the layer (Figs. 1 and 2) but, in some cases, may span the entire height of the molecular layer, reaching the pia mater (Fig. 4). ...five of these cells exhibit an axonal collateral which runs for long distances in the supraganglionic plexus, just above the apexes of PC somata. These collaterals follow a transverse direction, parallel to the great axis of the folium, i.e. exactly in the same direction as the parallel fibers. Such a collateral is identical to similar fibers found in Lugaro cell axons (Lugaro, 1894; Fox, 1959; LaineĀ¤ and Axelrad, 1996). Moreover, as in the case of Lugaro cells, this type of long collateral does not seem present in all the globular neurons of our series.synonim
Detailed morphological analysis has recently revealed that these cells project their axon into the molecular layer, where it displays an arborization pattern reminiscent of that of Lugaro cells. Furthermore, their cell body and dendrites are contacted by Purkinje cell collaterals, a feature characteristic of Lugaro cells. Consequently, these cells represent a class of neuronal cells in the granular layer that does not fit the current classification. To designate these cells, and to differentiate them from Golgi cells and classical bipolar Lugaro cells, we propose the term 'multipolar Lugaro cell'.Geurts F.J., de Schutter E. & Dieudonne S.Mihail Bota